Overview

    The Special Interest Groups (SIGs) represent the scientific diversity of EMGS. The SIG meetings are a time-tested favorite of the Annual Meeting. The SIG morning meeting format provides free-form discussions and short presentations of the key challenges and research. The SIGs provide a casual way for young investigators and seasoned researchers to interact. The SIGs also play a major role in proposing and running some of the symposia and workshops during the Annual Meeting.

    Special Interest Group Leaders Chair: Janet E. Baulch
    Special Interest Group Leaders Co-Chair: Catherine B. Klein
     

     

    Applied Genetic Toxicology SIG  

    The Applied Genetic Toxicology SIG is looking to gather people form a wide variety of backgrounds including pharmaceutics, consumer products, chemical products, food sciences and environmental researchers to discuss emerging science and regulatory issues that are highly relevant to applied genetic toxicology. We aim to provide a forum where members from industry, regulatory agencies and academia can meet to discuss common issues. SIG members and leadership will drive the annual agenda, focusing on key topics and issues that genetic toxicologists are currently facing. Partnering with other SIGs such as the Risk Assessment SIG we plan to help support EMGS strategic planning. We aim to accomplish our goals through a morning breakfast meeting and sponsorship of workshops at the annual meeting, along with periodic communications through the year to members.

    SIG Leaders

    Maria Donner, Chair; Rosalie K. Elespuru, , Co-Chair; and Julie Cox, Young Investigator Co-Chair 

     

    DNA Repair & Mutagenic Mechanisms SIG

    The DNA Repair Special Interest Group brings together EMGS members interested in DNA repair and related areas such as DNA damage, genomic instability, DNA damage responses, mutagensis and cell death pathways. At the EMGS Annual Meeting we meet for breakfast and informally discuss a topic of interest for the group. We also brainstorm about topics of symposia and keynote lectures for the next year’s EMGS meeting and representatives bring these ideas to the program committee meeting the last day of the meeting.

    More information about the EMGS DNA Repair and Mutagenic Mechanisms SIG is located on their Web site.

    SIG Leaders

    Andrew Buermeyer, Co-Chair, and Diane Cabelof, Young Investigator Co-Chair

     

    Environmental Genetic Toxicology SIG

    The Environmental Genetic Toxicology SIG is broad in scope and is for scientists interested in the genetic effects of contaminant exposure through air, water, soil, food, or physical contact. SIG members examine endpoints in the laboratory and/or field, and in model systems or natural populations. Synthesis across a broad range of assays and organisms is particularly encouraged by this group.

    SIG Leaders

    Jeffrey Wickliffe, Chair; Mark Wilson, Co-Chair

     

    Epigenetics SIG

    Epigenetics is a new Special Interest Group. EMGS members who are doing epigenetic research, wish to do so, or are just curious are encouraged to become participants of this SIG.

    Human epidemiological and animal experimental data indicate that the risk of developing adult-onset chronic diseases like cardiovascular disease, diabetes, obesity, and cancer is influenced by persistent adaptations to prenatal and early postnatal nutrition. Two epigenomic targets that potentially link environmental conditions during early development to adult disease susceptibility are imprinted genes and those with metastable epialleles. Genomic imprinting is an epigenetic form of gene regulation that results in monoallelic, parent-of-origin dependent gene expression. Genes with metastable epialleles have highly variable functions because of stochastic allelic changes in the epigenome rather than mutations in the genome. The importance of epigenetic deregulation of such genes in determining human risk to environmentally-induced diseases is now being actively investigated.

    SIG Leaders

    Janice Pluth, Chair; Daneida Lizarraga, Co-Chair; and Caren Weinhouse, Young Investigator Co-Chair

     

    Heritable Mutation & Disease SIG

    The Heritable Mutation and Disease Special Interest Group is for scientists interested in heritable mutagenesis, the challenges of finding human genomic DNA damaging agents, germ-cell and stem-cell mutagens, and the consequences of these mutations to health.

    SIG Leaders

    Patrick Allard, Co-Chair; Mike Waters, Co-Chair; and Marc Beal, New Investigator Co-Chair

     

    Molecular Epidemiology SIG

    Molecular Epidemiology Special Interest Group plays a major role in the assessment of the causative associations between exposures to environmental agents, hot factors of susceptibility, and the risks of genetic diseases including cancer and birth defects. This SIG identifies the latest research advances in the development of valid biomarkers of exposure, susceptibility and disease risks.

    SIG Leaders

    Miriam Poirier, Chair, Ainsley Weston, Co-Chair, and Karen Huen Northcote, Young Investigator Co-Chair

     

    New Technologies SIG

    The mission of the New Technologies Special Interest Group is to provide a forum for discussion on existing and emerging technologies that relate to current topics in the field of mutagenesis, genetic toxicology, molecular epidemiology and toxicology. Relevant activities of this SIG may include, but are not limited to, organizing and/or sponsoring symposia, roundtable discussions, workshops; Inviting speakers to introduce new technologies, and discuss their strengths and limitations. In addition, this SIG will provide a platform for academia, industry and government agencies for discussion and guidance in incorporating new technologies into the risk assessment and safety evaluation process. Topics chosen for the proposed activities of the SIG will focus on those areas of new emerging science and technology that are deemed most likely to be of broad enough interest so as to be relevant to existing Society members while, by virtue of novel content, attracting new members; in this way, expanding the scope of the Society.

    SIG Leaders

    Patricia A. Escobar, Chair

     

    Risk Assessment SIG

    The Risk Assessment Special Interest Group is a mid-sized, eclectic, and congenial group of individuals with shared interests in the broad area of risk assessment, particularly as it relates to genetic toxicology, mutagenesis, and carcinogenesis. This core group of scientist within EMGS has been assembling each year at the EMGS Meeting since 1997 to discuss a wide range of topics that are pertinent to risk assessment. Topics that have been discussed in the Risk Assessment SIG meetings include different approaches for risk analysis and low-dose extrapolation, the use of cancer biomarkers, the use of transgenic animal data in risk assessment, different government agency approaches to risk assessment, establishing chemical mode-of-action, and the application of the genetic toxicology tests to risk assessment.

    One of the strengths of the Risk Assessment SIG is our diversity. Our meetings are usually well-attended by scientists from government regulatory agencies from several countries, academia, pharmaceutical companies, chemical companies, and contract laboratories. This diversity in background and perspective leads to the stimulating informal discussions that are a hallmark of EMGS, in general, and the Risk Assessment SIG, in particular. At our SIG breakfast meetings, we always run out of time for discussion before the attendees run out of things to say!

    Beyond the Risk Assessment SIG meeting, which takes place every year as part of the EMGS Annual Meeting, members can share information with other Risk Assessment SIG members via a monitored e-mail distribution list. Information of general interest to the Risk Assessment SIG can be forwarded to the Group Leaders for distribution to the SIG membership. The e-mail contact list is also used to solicit suggestions for speakers and topics for upcoming Risk Assessment SIG breakfast meetings. Finally, the Risk Assessment SIG has compiled a list of many valuable links to online resources used by the Risk Assessment community that can be accessed from our SIG webpage. We encourage EMGS members with an interest in Risk Assessment to become active participants in our SIG!

    SIG Leaders

    Brinda Mahadevan;Chair and Catherine Faye Gibbons;, Co-Chair, and Isheeta Seth, New Investigator Co-Chair

     

    Transgenics & In Vivo Mutagenesis SIG

    The Transgenic and In Vivo Mutagenesis Special Interest Group focuses on recent research measuring the frequency of mutation in tissues in whole animals. The Hprt lymphocyte assay has been a major tool for this research, which has been augmented by Aprt and Tk assays. However, these assays depend upon the ability to culture cells in vitro in order to apply the selection medium to identify mutants.

    In the last 2 decades, transgenic animals, which contain tandem genomic insertions of bacterial genes have been used to measure in vivo mutation frequencies. These systems allow the identification of mutations in bacterial assays from any tissue from which sufficient DNA can be obtained to measure a mutant frequency. These transgenes include the following bacterial or viral targets: lacI (Big Blue , lacZ (MutaMouse ), cII (used with either Big Blue or MutaMouse); gpt delta, lacZ plasmid, and ΦX174 (Malling Mouse). Research with these tools has focused on validation of in vivo mutation, change in mutant frequency with age and tissue, and, particularly, the increase in mutant frequency with exogenous mutagens. Sequencing of mutants can add useful information in the interpretation of changes (or lack of change) in mutant frequencies.

    SIG Leaders

    Nan Mei, Chair and Alexandra Long, Co-Chair

     

    Women in the EMGS

    The Women in the EMGS (WEMGS) group focuses on women’s issues within the EMGS as well as broader issues that face many women in scientific careers.

    The mission of WEMGS is to:

    Create opportunities for networking and mentoring for women.
    Encourage leadership and career development.
    Encourage and support representation of women throughout the society and within the scientific community.
    During the EMGS meetings, WEMGS provides a forum for discussions focusing on general issues that affect not only women but which are relevant to the general membership of the EMGS. We develop ideas for symposia and topics to be considered by the EMGS program committee for upcoming EMGS meetings.

    If you are interested in becoming involved either as a committee member or would like to give your input into programming ideas for discussions or EMGS program ideas, we encourage any EMGS member to join the WEMGS special interest group. ALL are welcome to attend our meetings and WEMGS hosted EMGS meetings sessions!

    Group Leaders

    Kristine Witt, Chair and Meagan Myers, Co-Chair

     

     

     


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